Engineering Mechanics

Proceedings Vol. 10 (2004)

ENGINEERING MECHANICS 2004

NATIONAL CONFERENCE WITH INTERNATIONAL PARTICIPATION
May 10 – 13, 2004, Svratka, Czech Republic

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Editors: Igor Zolotarev and Alena Poživilová

ISBN 80-85918-88-9 (printed)
ISSN 1805-8248 (printed)
ISSN 1805-8256 (electronic)

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Ionic concentration changes in the tubular system of rat ventricular cardiac cell model

Pásek M., Christé G., Šimurda J.
pages 227 - +9p., full text

We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and the distribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload.

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Engineering Mechanics

International Conference

Proceedings Vol. 10 (2004)

ENGINEERING MECHANICS 2004