Engineering Mechanics

Proceedings Vol. 20 (2014)

ENGINEERING MECHANICS 2014

Copyright © 2014 Brno University of Technology Institute of Solid Mechanics, Mechatronics and Biomechanics

 

Pásek M., Šimurda J., Christé G.
pages 499 - 502, full text

The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimate the impact of individual ionic currents on AP configuration, mathematical models have been widely used. In this study, we compare the effects of alcohol-induced changes of IK1 on AP duration (APD) as simulated in four recently published computer models of human ventricular cells. As expected, increasing or decreasing I K1 conductance by 20% respectively caused a shortening or a lengthening of APD. However, the effect was largely model-dependent, ranging from 1% to about 15% change of APD. Given the conflicting available experimental data on the features of IK1 in human ventricular myocytes there is a need for a set of well-established end-point constraints for a reliable human ventricular myocyte model to be generated.

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